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1.
Six pregnane alkaloids were isolated from the root of Sarcococca ruscifolia. The structures of three new alkaloids, namely, sarcorucinine E–G (1–3), were elucidated using spectroscopic methods, while three known alkaloids, namely, epipachysamine D, pachysamine M, and sarcovagine D, were identified by comparing their spectral data with those of the compounds reported earlier. All compounds were evaluated for their inhibitory activities against multiple types of cancer cells. 相似文献
2.
The utility of HPTLC and HILIC/ESI-QTOF-MS for the determination of pyrrolizidine alkaloids (PAs) and their N-oxides (PANOs) was compared in the selected plant species: Tussilago farfara L. (TF, flower) and Arnebia euchroma (Royle) I.M. Johnst. (AE, root). HPTLC confirmed the postulated presence of PAs (saturated and unsaturated) or PANOs in the tested extracts. In accordance with previous studies, HILIC/ESI-Q-TOF-MS confirmed the presence of the toxic PA senkirkine and the saturated otonecine-type PAs, tussilagine and isotussilagine in the TF extract and 7-angeloylretronecine and 9-angeloylretronecine in AE extract. Moreover, the following alkaloids were identified in AE root: intermedine, intermedine-N-oxide, leptanthine-N-oxide, echimidine-N-oxide (or their corresponding stereoisomers) and traces of 7-angeloylretronecine and 9-angeloylretronecine-N-oxide. The study demonstrates the HILIC/ESI-Q-TOF-MS method to be a very useful tool for monitoring PAs and PANOs in the test samples, even when not all of the necessary standards are available. Quantitative analysis of senkirkine in TF flower by HILIC/ESI-QTOF-MS featured high resolution, high precision, high mass accuracy, and very high sensitivity with limit-of-detection (LOD) of 27.50 fg/μL and limit-of-quantitation (LOQ) of 91.60 fg/μL. The results from both methods may be used for the development or rejection of European Pharmacopoeia (X) monographs of both investigated species. 相似文献
3.
T. A. Jaarsma E. Lohmanns H. Hendriks T. W. J. Gadella T. M. Malingré 《Plant Systematics and Evolution》1990,169(1-2):31-39
InS. tuberosum subspp.tuberosum andnodosum, S. grandiflorum andS. ibericum the presence of the pyrrolizidine alkaloids lycopsamine, echimidine and symphytine could be demonstrated. The taxonS. tuberosum contains an unknown compound that seems to be specific for this taxon. This compound is not the pyrrolizidine alkaloid anadoline which has previously been reported for this species. It is possibly represented by a peak on GC/MS with a molecular ion peak at m/z 623 (as TMS derivative) and can be used as a chemotaxonomic marker for the speciesS. tuberosum. The pyrrolizidine alkaloid pattern of the two subspecies ofS. tuberosum reinforces the close relationship. Fresh material ofS. tuberosum contained the triterpene isobauerenol, but in herbarium material isobauerenol was lacking. InS. grandiflorum, neither fresh nor dried material contains isobauerenol. In herbarium material ofS. ibericum also no isobauerenol could be found. More extensive chemotaxonomical research is necessary to support the view thatS. abchasicum is more closely related toS. ibericum than toS. grandiflorum. 相似文献
4.
Phytochemical investigation of roots from Solanum asterophorum led to the identification of 37 compounds, including 9 phenolic acid derivatives, 2 alkamides, 7 hydroxy-carboxylic acid derivatives, and 19 steroidal alkaloids. The dereplication of compounds was performed by extensive analysis by ultra-performance liquid chromatography coupled with a diode array and quadrupole time-of-flight mass spectrometry. With the exception of alkaloid isojurubidine, all compounds were reported from Solanum asterophorum for the first time. The chemotaxonomic significance of the isolated compounds was discussed. 相似文献
5.
R. Zárate 《Plant cell reports》1999,18(5):418-423
Atropa baetica hairy root cultures were induced after infecting stem segments with Agrobacterium rhizogenes strain ATCC 15834. Accumulation of the tropane alkaloids atropine and scopolamine by hairy roots cultured in half- and full-strength
Murashige and Skoog (MS) medium was high, although this was not growth associated. These alkaloids were also released into
both liquid media. Higher tropane alkaloids present both in hairy roots and liquid medium occurred in half MS medium, showing
a clear relationship between slow growth of cultures and higher product accumulation. The pH of both nutrient media varied
as culture progressed, and seemed to be associated with the release of scopolamine. GC-MS analyses showed the presence of
a new compound, namely tigloylpseudotropine; moreover, 3α-isobutyryloxytropane, formerly found only in plant leaf tissue,
was also identified in the hairy roots.
Received: 18 August 1997 / Revision received: 30 November 1997 / Accepted: 20 January 1998 相似文献
6.
A comparison of the morphology and of the venom alkaloids of the Australian Monomorium rothsteini complex was undertaken. These ants were collected in Australia from western New South Wales, northern Queensland, and northern Northern Territory. Additionally, samples from the M. sordidum complex and M. carinatum complex were examined. Thirteen previously described trans‐2,5‐dialkylpyrrolidines were detected in these ants, along with the novel trans‐2‐ethyl‐5‐[(Z)‐tridec‐4‐enyl]pyrrolidine ( 6 ), whose structure was confirmed by synthesis. The extent of variation and the correlation observed in the morphology and venom chemistry in M. rothsteini samples is very strongly indicative of multiple species in this complex. The presence and location of the C?C bond in 6 reinforces the remarkable structural similarity of the 2‐ethylpyrrolidines in these Monomorium species to the 2‐methylpiperidines in the venoms of many Solenopsis species, and may represent convergent evolution of biosynthetic processes in different genera of solenopsidine ants. 相似文献
7.
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9.
From the root bark of Hovenia dulcis Thunb. and H. tommentella (Makino) Nakai (Rhamnaceae), three peptide alkaloids, frangulanine, hovenins-A and -B have been isolated. Hovenin-A has been shown to be des-N-methylfrangulanine (II). 相似文献
10.